Transgenic Rice and Potato Plants Expressing Human Cytochrome P450s Show Cross-tolerance to Herbicides by Detoxifying Them
نویسندگان
چکیده
Transgenic plants expressing various species of the detoxifying enzyme, cytochrome P450 monooxigenase from mammals, were bred by Agrobacterium-mediated transformation. The transgenic plants metabolized exogenous chemicals, including herbicides which they were able to tolerate. Because the enzymes had broad substrate specificity, the transgenic plants showed crosstolerance to several herbicides, even though these had different modes of action and different chemical structures. Plants with cross-tolerance can be used in a herbicide rotation system, to avoid or delay the evolution of herbicide-resistant weeds. The transgenic plants are also expected to reduce the environmental load of agricultural chemicals on farmland.
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